MEDTRONIC 48145 OXY Nautilus ECMO w BalanceBiosurtace

Condition: New
Part #: MEDTRONIC 48145

$4,000.00

SKU: MEDTRONIC 48145 Categories: , ,
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Description

The Medtronic 48145 Nautilus ECMO Oxygenator with Balance Biosurface represents a significant advancement in extracorporeal life support (ECLS). Engineered for patients experiencing severe cardiac or respiratory failure, this single-use oxygenator is designed to provide reliable, long-term gas exchange. By combining a unique circular flow-path with advanced biocompatible coatings, the Nautilus 48145 ensures high-efficiency performance while prioritizing patient safety and circuit stability.


Core Technology

The Nautilus 48145 is built upon two foundational technological pillars that set it apart from conventional oxygenator designs:

  • Circular Flow-Path Design: Unlike standard radial designs that can suffer from “dead zones” where blood stagnates, the Nautilus utilizes a circular path. This promotes uniform blood distribution across the fiber bundle, reducing the risk of localized clotting.

  • Balance Biosurface Coating: To mitigate the body’s natural inflammatory response to foreign surfaces, the device features Balance Biosurface. This hydrophilic, heparin-free coating improves biocompatibility and significantly reduces thrombus formation during extended ECMO runs.

  • Polymethylpentene (PMP) Membrane: The 1.8 m² PMP hollow-fiber membrane provides a robust barrier for gas exchange, preventing plasma leakage—a common failure point in older polypropylene-based oxygenators.


Mechanism of Action

The Nautilus 48145 functions as the “artificial lung” within an ECMO circuit. Venous blood is pumped into the oxygenator, where it enters the circular flow-path. As blood passes over the PMP hollow fibers, oxygen ($O_2$) diffuses into the blood while carbon dioxide ($CO_2$) is removed via a partial pressure gradient.

Simultaneously, an integrated heat exchanger allows clinicians to precisely regulate the patient’s blood temperature. The low pressure drop across the device ensures that the cellular components of the blood (erythrocytes and platelets) undergo minimal mechanical stress, preserving hematologic integrity over long-term therapy.


Clinical Applications

The Medtronic Nautilus 48145 is indicated for use in adult patients requiring extracorporeal circulation for periods exceeding six hours. Key applications include:

  • Severe ARDS: Providing lung rest for patients with refractory respiratory failure.

  • Cardiogenic Shock: Supporting systemic circulation post-myocardial infarction or during acute heart failure.

  • Bridge to Transplant: Maintaining patient stability while awaiting lung or heart transplantation.

  • Post-Cardiotomy ECLS: Support for patients unable to be weaned from cardiopulmonary bypass.


Key Advantages

  • High Flow Capacity: Supports flow rates up to 7 L/min, making it suitable for a wide range of adult patient sizes and metabolic demands.

  • Optimized Priming: A compact 226 mL priming volume reduces the need for hemodilution or blood product use during circuit initiation.

  • Enhanced Gas Transfer: Specifically rated for $266 \text{ mL/min}$ $O_2$ transfer, ensuring adequate systemic oxygenation even in high-demand states.

  • Extended Durability: The PMP membrane and Balance Biosurface are specifically validated for the rigors of long-term ECMO therapy, maintaining performance for days or weeks.


Technical Specifications

Feature Specification
Model Number 48145
Membrane Type Polymethylpentene (PMP)
Surface Area 1.8 m²
Max Blood Flow 7.0 L/min
Priming Volume 226 mL
Surface Coating Balance Biosurface
Inlet/Outlet Ports 3/8″ (9.5 mm)
Max Pressure 750 mmHg
$O_2$ Transfer Rate 266 mL/min (at max flow)
$CO_2$ Removal Rate 186 mL/min (at max flow)

Frequently Asked Questions

What is the primary benefit of the circular flow-path in the Nautilus 48145?

The circular flow-path is engineered to eliminate stagnant areas within the oxygenator. By ensuring a uniform and consistent blood flow across the entire PMP membrane, the design significantly reduces the likelihood of thrombus formation (clotting), which is a common complication in conventional radial-flow ECMO devices during long-term use.

How does Balance Biosurface improve patient outcomes?

Balance Biosurface is a proprietary biocompatible coating that reduces the activation of platelets and the coagulation cascade. By minimizing the interaction between the blood and the synthetic materials of the oxygenator, it helps maintain more stable hematologic profiles and reduces the clinical need for aggressive systemic anticoagulation in some patients.

Can this oxygenator be used for both VA and VV ECMO?

Yes, the Medtronic Nautilus 48145 is versatile enough to be integrated into both Veno-Venous (VV) and Veno-Arterial (VA) ECMO configurations. Its high flow capacity of 7 L/min and efficient $CO_2$ removal make it ideal for both total respiratory support and full hemodynamic cardiac support in adult patients.

What is the significance of the PMP membrane in this device?

Polymethylpentene (PMP) is a non-porous material that allows for gas diffusion without the risk of plasma leakage. Unlike older microporous membranes that could fail after a few days, PMP membranes like the one in the Nautilus 48145 are designed for the durability required in extended-duration extracorporeal life support.

Does the Nautilus 48145 include an integrated heat exchanger?

Yes, the device features a high-efficiency integrated heat exchanger. This allows clinicians to manage the patient’s core body temperature directly through the ECMO circuit, which is critical for treating patients in cardiogenic shock or those requiring targeted temperature management after cardiac arrest or major surgery.

What are the pressure limits for the Nautilus 48145?

The Nautilus 48145 is built to withstand high-pressure environments common in complex ECLS circuits. It is rated for a maximum blood-side pressure of 750 mmHg. This robustness ensures that the device can handle high flow rates and potential pressure spikes without compromising the integrity of the membrane or housing.

Listing Terms & Conditions

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